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KMID : 0377519900150040357
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Chung-Ang Journal of Medicine
1990 Volume.15 No. 4 p.357 ~ p.367
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Effects of Prednisolone and Cyclosporin A on the Inflammation Produced by superoxide Radical in Guinea Pig Skin
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Abstract
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The purpose of this study was to investigate the effects of prednisolonc (PDL) and cyclosporin A (CsA) on the inflammation induced by superoxide radicals. Experimentally inflammatory reaction was produced by intradermal injection of xanthine oxidase (XOD) and hypoxanthine (HPX) (control) into guinea pig skin. The authors observed changes in activities of superoxide dismutase (SOD)and catalase, and the production of superoxide radicals in the groups injected intraperitoneally of PDL (group A) and CsA (group B) concomitantly.
The results were as follows:
1. Activities of total SOD in group A and group B were increased compared with control, and significantly higher (p<0.01) at the 12 hour and 24 hour points. But there were no significant differences between group A and B in SOD activity.
2. The time course changes of catalase activity in group A and B were similar to those of SOD.
In group A and B, catalase activities were significantly higher (p<0.01) at 3 hour point than
control, and remained significantly up to 48 hours. In group B, significant increase of catalase
activity was observed at ;l 2 hour point (p<0.01) and significant reduce at 48 hour point (p<0.01).
3. The time course of change in the superoxide radical production was contrast to those of SOD
and catalase activities. The significant reduces were observed 12 hours after injection in group
A (p<0.01) and 3´ hours after injection in group B (p<0.05). In group B, superoxide radical pro-
duction was significantly higher than group A only at the 12 hour point after injection (p<0.01).
These findings suggest that PDL and CsA lead to the increased production of SOD and catalase activities in the early phase of inflammation produced by superoxide radical, and that PDL sup-press the production of superoxide radical more rapidly than CsA.
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